6/11/2023 0 Comments Keynote 057![]() Because we might have some biases related to the quality of the TURBT and some other biases, they could be adjusted just with a randomisation design rather than with monotherapy and single-arm design. The major point is that the US FDA and the regulators are requiring randomised studies with any newer therapies in order to provide a new standard of care in this patient population. It may have a huge impact because the non-CIS patient population is a consistent patient population, pretty well defined by the guidelines. How can the study results impact clinical practice? This is important data and these data are coupled with the confirmed safety outcomes that are in line with the safety outcome already provided in various disease settings with monotherapy with pembrolizumab, including cohort A of the study, with stable quality of life parameters over time, meaning that the combination of safety and efficacy in the all-comers and in the PD-L1 positive and negative subgroups may justify a potential expansion of the indication of pembrolizumab besides the CIS population, also including the BCG unresponsive papillary tumours. So a signal for numerically higher maintained responses with PD-L1 positive tumours but, at the same time, the main message providing the efficacy and confirming the efficacy of pembrolizumab regardless, mainly, of PD-L1 expression. If we look at the subgroup analysis by PD-L1 expression, stratified by CPS combined positive score expression of PD-L1 based on the DAKO platform, we realised that patients with PD-L1 high tumours benefitted with a twelve-month disease-free survival rate of 54% while for PD-L1 negative tumours the rate of the twelve-month disease-free survival for high-risk disease recurrence was 39%. The overall findings from this cohort, which included 132 patients, were related to the fact that the primary endpoint consisting of the twelve-month disease-free survival for high-risk disease recurrence was 43% in the ITT population. This is a very special patient population for which we don’t have any standard of care, any robust standard of care, and for which there is limited opportunity for inclusion in clinical trials. The cohort B of the study, which is the focus of this meeting presentation, is related to the patients with BCG unresponsive non-CIS tumours, so papillary tumours, pTa or pT1, unresponsive to BCG. ![]() Cohort A of the study, of the KEYNOTE-057, already provided data on the activity of pembrolizumab monotherapy in patients with carcinoma in situ components with or without papillary tumours and resulted in 40% response, complete response, at three months with about one-third of the responses maintained over time long-term, and resulted in the US FDA approval of pembrolizumab monotherapy in patients with BCG unresponsive CIS population. So, for this patient population there is still an unmet medical need. The KEYNOTE-057 study is a multicentre phase II study investigating multiple cohorts of patients with high-risk non-muscle invasive bladder cancer whose disease has failed, has relapsed, after adequate BCG therapy. I will present at this congress the update related to the cohort B of the KEYNOTE-057 study.
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6/11/2023 0 Comments Gmail stock icons disappearedThen you can check your inbox to see if you can find your emails. Type your mail address and password to re-add mail account on your iPhone. Then go back to "Mail, Contacts, Calendars" and choose "Add Account" option. On your iPhone, please go to "Settings" > "Mail, Contacts, Calendars", find and enter your mail account, and select "Delete Account" option. You can try to delete the email account and re-add it on your iPhone and see if works. If iPhone emails keep disappearing after force reboot, there may be an error with the email account. Delete and Re-add Email Account on iPhone See Also: How to Fix iPhone Stuck in Reboot Loop Keep hold the Power + Volume Down buttons simultaneously for at least 10 seconds till the iPhone screen goes black and Apple logo shows on the screen, release the two buttons. Your iPhone will be restarted and the Apple logo will appear on the screen soon. When the screen turns black, release the two buttons. Please press and hold the Power + Home buttons at the same time for at least 10 seconds. On iPhone 6/6 Plus/6s/6s Plus/5s and older generations: Now, please follow the instructions as below to force reboot your iPhone to fix the problem. Hard reboot an iPhone can solve most of iPhone system crashes in most cases, including the email disappearing from iPhone issue due to system crashes. Force Restart iPhone to Fix Email Disappearing from iPhone Issue Four Solutions to Fix Email Disappearing from iPhone 11/11 Pro/11 Pro Max/XSĪfter knowing the likely reasons to cause email disappearing from iPhone, you can read on to learn the effective ways to solve the disappeared email issue on iPhone in this part. See Also: Top 10 Tips to Fix iPhone Won't Connect to Wi-Fi Problem Part 2. In a word, there is a conflict between POP3 and IMAP, which causes emails disappearing from iPhone. And IMAP simply make a copy without removing emails from email server unless you set up that, and importantly, the email server is the official place to keep the emails, not your device. However, most of email programs on on mobile phone use a different protocol called IMAP to access email. As a result, the email is copied to your computer and removed from the email server. And by default, the POP3 moves or download the email from the email server to your computer. Most desktop email programs are configured to use POP3 email fetching protocol. The system error is one of the common reasons to cause mails disappearing from iPhone inbox.ģ. Even though iPhone acts as one of the most advanced digital devices on the world, the iPhone system crashes issue happens from time to time. If the Mail app is not set up properly, it may lead to mails disappearing from iPhone inbox.Ģ. iPhone allows you to customize the Mail app with several mail settings. ![]() Relax, you can check the possible reasons as follows before fixing email disappearing from iPhone issue.ġ. It is quiet annoying to lose the valuable emails from your iPhone 11/11 Pro/11 Pro Max/XR/XS/XS Max/X/8 Plus/8/7 Plus/7/6s Plus/6s/6 Plus/6/5S/SE with no reason. Why Does Email Disappear from iPhone Inbox? ![]() ![]() Four Solutions to Fix Email Disappearing from iPhone 11/11 Pro/11 Pro Max Part 1. Why Does Email Disappear from iPhone Inbox So why are email disappearing from iPhone for no reason? And how to fix email disappearing from iPhone? Let's find out the reasons and solutions in this article together. However, sometimes it is also easy to misconfigure things when adding a phone, like an iPhone, to access your email, which makes emails seemingly disappear. Has this been happening to anyone else? Anybody know how to fix this problem? Thanks!"ĭue to the portability of smartphones, people tend to send and read emails on their iPhone or Android device. "I have an iPhone 8 running iOS 11 and the past couple of days I've noticed that various emails are disappearing from my inbox - some after I've read them, and some after I've gotten a notification but haven't opened the email yet. 6/11/2023 0 Comments Avast free![]() If you prefer to enable cookies only for webpages that are part of the domain, follow the steps below: Mozilla Support ▸ Websites say cookies are blocked - Unblock them.To manage your global cookie preferences for all websites that you visit using Mozilla Firefox, refer to the following article from Mozilla Support: Mozilla Support ▸ JavaScript settings and preferences for interactive web pages.For more information about JavaScript settings in Mozilla Firefox, refer to the following article from Mozilla Support: If you have disabled JavaScript using a browser add-on that allows you to customize your JavaScript settings, you need to re-enable JavaScript using this add-on. JavaScript is enabled for all websites by default in Mozilla Firefox. Google Chrome Help ▸ Clear, enable, and manage cookies in Chrome.To manage your cookie preferences in Google Chrome, refer to the instructions under Change your cookie settings in the following article from Google Chrome Help: This means that all webpages with a web address beginning (such as allow JavaScript. Click the Add button next to Allowed to use JavaScript.Ī now appears on your Allowed to use JavaScript list.Click Privacy and security ▸ Site Settings. ![]() If you prefer to enable JavaScript only for webpages that are part of the domain, follow the steps below:
6/11/2023 0 Comments Nine dots 4 lines![]() Roseville, CA - Ktm For Sale - Ktm Motorcycles - Cycle …. We consider individuals for employment or promotion according to their skills, abilities, and experience. Ross is an equal employment opportunity employer. One year of loss prevention/security training is preferred. Store Protection Specialist (FT) New Orleans, LA. Store Protection Specialist (FT) Job in New Orleans, LA | Glassdoor. How to find ross dress for less locations near me Open Google Maps on your computer or APP, just type an address or name of a place. Contact a location near you for products or services. The ross dress for less locations locations can help with all your needs. CEO and Founder, Chelsea Phillips, introduced us to some adorable baby animals and even let.
6/11/2023 0 Comments Peggy webber![]() The Screaming Skull was directed by Alex Nicol, an actor who had roles on Broadway productions and often played supporting characters. I just worked my way through the script, blocking it out as I went along, trying to get the film shot on time." "There wasn't any one director I tried to emulate on that film I wasn't smart enough to do that. Rest in peace." A vision of a woman's face appears in the pond. The film ends with Mickey drinking from the pond and saying "They've left. Reverend Snow declares whether or not Marion's death was an accident will remain a mystery. Some undisclosed time later, Jenni and the Snows depart from the house. Snow comforts a hysterical Jenni and the Reverend discovers Eric's body in the pond. The ghost appears and chases Eric outside, corners, and attacks him, drowning him in the decorative pond.Īfter Jenni regains consciousness, the Snows arrive. Jenni sees Marion's ghost in Mickey's greenhouse and flees back to the house, where Eric begins throttling her. That night, Eric prepares to murder Jenni and stage it as a suicide. Mickey secretly steals the skull and brings it to Snow before Eric can retrieve it. She tells Eric that the entire property will be meticulously searched for the skull as a last resort. As Jenni faints, Eric withdraws the skull and hides it, revealing that he has been gaslighting her all along.īelieving she has finally lost her sanity, Jenni resolves to be committed. Jenni panics at the sight of the skull, but Eric denies that the skull is there. Eric and Jenni take the painting outside and burn it, later uncovering a skull from the ashes. Eric suggests that they remove Marion's self-portrait from the home. Though Eric speculates to Jenni that Mickey, who was a childhood friend of Marion and thus dislikes Jenni, may be behind the trickery, Jenni worries that she is going insane. When she begins to hear unexplained screaming noises and see skulls around the house, she believes that Marion is haunting her. Jenni is disturbed both by Mickey's belief that Marion's ghost wanders the estate and by Marion's self-portrait inside the house, which Jenni believes resembles her mother. Eric privately mentions to the Snows that Jenni spent time in an asylum following the sudden death of both her parents, who were also drowned, and Mrs. At the home they meet Eric's friends, the Reverend Snow and his wife, as well as Mickey, the mentally disabled gardener. It is revealed that Jenni is Eric's second wife: his first wife Marion died when she accidentally slipped and hit her head on the edge of a decorative pond on the estate, drowning in the pond. Newlyweds Jenni and Eric arrive at Eric's palatial country home in a gull-wing Mercedes-Benz 300 SL. Inside the coffin is a card that reads "Reserved for You." Over a scene of an opening coffin, a narrator explains that the film's climax is so terrifying that it may kill the viewer, while reassuring the audience that should they die of fright they will receive a free burial service. She had regular appearances, in these, playing her age, on TV’s Dragnet.An opening prologue explains that The Screaming Skull is so frightening that it may kill its viewers. ![]() Unlike some radio stars (Bill Conrad of Gunsmoke, for one), Peggy made the transition to TV. ![]() Hearing Dragnet today as a regular feature on SiriusXm “Radio Classics,” I am always impressed when Friday comes home at some unGodly hour and mom invariably has some meatloaf in the icebox for her Joseph. Peggy, known for her wide range of voices, played the concerned mother of this L.A.P.D. Joe was a bachelor his mother called him “Joseph.” It would have a Los Angeles Police Department detective named Joe Friday. He had an idea for a new radio program: Dragnet. After the show, Jack said, “Peg, why don’t you stick around?” In 1949, both also had gigs on a This is Your F.B.I. Peggy first worked with Jack Webb on his Pat Novak for Hire radio series in the late 1940s. If they weren’t paying attention, he would then whiplash them with words they had never heard before.” But when we were working on the movie, he was very cruel to the workers, the sound men and the grips. Welles was known for being imperious, but Peggy recalls, “… generally speaking, Orson loved actors and didn’t give them a bad time…. Webber as Lady Macduff in Orson Welles’ Macbeth. 6/10/2023 0 Comments Crime patrol satark 6th march 2017![]() Palm Bay City Council workshop meeting on the Compound Palm … Crime Patrol Dial 100 Latest 15th April 2017s. CRIME PATROL SATARK - 15th April 2017 - Case 26 %2F 2017.normas del buen hablante para niños de tercer gradoĬrime Patrol 15th April 2017 - video Dailymotion Tue 13.44 EDT First published on Mon 18.10 EDT.Web825 views, 21 likes, 1 loves, 0 comments, 3 shares, Facebook Watch Videos from Jaguarpaw DeepforestSA: See No Evil 2023 S5E12 ps4 video clipsĪt least 22 killed, 59 injured in suicide attack at Manchester Arena See No Evil 2023 S5E12 See No Evil 2023 S5E12 By Jaguarpaw. WebPolice Scotland (Scottish Gaelic: Poileas Alba), officially the Police Service of Scotland (Seirbheis Phoilis na h-Alba), is the national police force of Scotland.It was formed in … The first season … normas del buen hablante para niños de cuarto grado WebCrime Patrol is an Indian crime anthology series created by Subramanian S.lyer for Sony Entertainment Television India and Sony Entertainment Television Asia. ![]() I was last assigned in DPD, to uniform patrol in the Eighth Precinct (far northwest area), working the day shift and in … WebThis also entailed dealing with power outages and one tornado. Julian Sage - Deputy Sheriff - Oakland County Sheriff
6/10/2023 0 Comments Adium google hangoutThe big downside to iMessage is that it only works on Apple products, and there's no website, which is pretty limiting compared to the usual "works with everything" client smorgasbord from (good) Google products. It has group chat, end-to-end encryption (for iMessage messages), voice messages, FaceTime video calls, and a million other features. ![]() We're not covering the full history of iMessage, but naturally having the full weight of Apple behind the service makes it a very competitive messaging app. I like to imagine Apple said something like, "Hey carriers, multiple partners means you are all now considerably less valuable to Apple! We're going to kill SMS. If you don't like it, there's the door." The truth, though, is that Apple didn't even feel the carriers were important enough to communicate with them. I think it's funny that this happened the same year AT&T's iPhone exclusivity ended and Verizon finally got to launch an iPhone. Carriers were apparently blindsided by the announcement of iMessage and Apple's commandeering of SMS. Cupertino couldn't care less about the feelings of AT&T et al. We'll later see Google acquiesce to the wishes of carriers and put SMS on a pedestal, but Apple was the polar opposite. iMessage messages synced to your Mac, and eventually, SMS forwarding arrived in 2014, so I guess you can say that's when the service fully powered-up. Therefore you could use iMessage to communicate with everyone, no matter what. As Apple was fond of saying at the time: it just worked. Apple's service was the SMS client on iOS, but it also pushed people over to the enhanced iMessage service whenever possible. IMessage quickly became the template for what users wanted from a Google Messaging system. The full power of the company is behind iMessage with no other distractions. In fact, Apple has never launched a competing messaging app in the nine years this service has been around. Apple did not release a second, competing messaging app 18 months after the launch of iMessage. End of article.Īpple launched iMessage along with iOS 5 in October 2011 and brought iMessage to the Mac with the release of OS X 10.8 Mountain Lion the next year. ![]() ![]() And now, a brief history of Apple Messaging services: iMessage. 6/10/2023 0 Comments Glam bedroomWhether you use a black velvet bed covering with gold satin pillows, or a mirror with a gold frame, this combination is totally glamorous. Go for a neutral shade, in a double height and see how much it changes the feel of the room. Black and gold flawlessly complement each other and add a deeply rich glamorous touch to any bedroom. 'A headboard will really create a focal point in your room, especially in a rich velvet', explains Victoria. 8 easy ways to add instant glamour to a bedroom You dont need to spend a fortune or to be an interior designer to create a glamorous and luxurious boudoir. Shop Design Fashion Travel Art Life Shop. The centerpiece of the collection, the stately bed, has a winged. ![]() Get interior design ideas & inspiration to add some glamor to your bohemian home, living room, bedroom, kitchen, etc. The Deanna glamorous collection will turn your bedroom into a palace with its opulent accents. MORE: 5 TIMELESS BEDROOM COLOUR SCHEMES THAT WORKĪward winning interiors blogger Victoria Jackson from Apartment 4shares a few of her ideas for a high-end looking bedroom – even if you're on a budget. Our top favorite boho chic design, rooms, and spaces - with timeless soft glam feels, mid-century furniture & decor, and artfully eclectic homes that. So why do most people neglect bedrooms as a place to decorate? Sure, some things (like lighting, wardrobes, beds or headboards etc) can be expensive, but sometimes all you need is a few great home accessories like pretty mirrors, some scatter cushions, some framed prints, organised shelves and a vase of flowers to make the world of difference. It's where you read, where you sleep and wake up, where you get ready for the day and where you rest at the end of it, and where you switch off. ![]() It's where you have your ultimate alone time. Your bedroom is one of the most important rooms of the home – if not the most important. Mid Century Modern furniture paired with vintage accents help bring this primary bedroom suite to life in this Ravenna bungalow. ![]() set file saving folder function and menu added processing movie position can be changed even during extracting all extracting frame pictures will be saved at highest resolution deprecated macOS functions all re-coded updated to macOS Sierra 10.12 and still compatible to OS10.8 and above Fix bug of nil output folder under OS 10.7 ![]() Sandboxed OS 10.6 - OS 10.8 compatible version ![]() output folder auto open after extraction status of extraction displayed on app's dock icon extraction can be manually interrupted anytime without issues. starting point can be set to any position of the video extracted frames can be placed in any folder picture files' name can be freely set, or using movie file's name pictures will be outputted in PNG format extracted pictures' resolution can also be freely set by simply changing the player's size preset to the highest resolution the video can provide fully supports all movie formats that can be opened by your QuickTime Player *For the reverse engineering, generating movie from pictures, please consider app named "picture2movie" and "photo2movie", there is also a free app named "photo2movie FREE". Still using snapshot or screen-capture on obtaining single frame image of a movie? Tired of fast forwarding, rewinding, and rewinding some more, but still cannot find the frame you want? Then movie2picture is just the one you need.ĭrag and drop a video file to movie2picture, and it will find the highest possible resolution images for you.Īfter you set up the resolution and a destination folder, your movie or video file will be extracted into pictures without losing a single frame. Price: $10.99 -> Free, Version: v3.05 ( iTunes)Įxtract all frames of your movie into high-resolution pictures!Īttention: for commercial use, more features or UHD and 4k videos and above please consider our "preCut Pro" 6/10/2023 0 Comments Mk 11 reddit![]() I read about all of them first, and thought Raiden was my guy.Until I saw one little sentence in the Shang's description. When I was little and didn't know about MK, my friend told me about sub-zero (his favorite) and all the other cool characters that game had (that happened when mk2 came out)and I was like "man, I need to know more about those characters and pick me a favorite". Labbing Impostor combos was very fun in MKX after all, I wouldn't mind doing it again!Īgreed about shapeshifting, that is what made him my favorite character in all fighting games, and made MK my favorite game. It's plus frames, restand and, depending on the match up, could be worth a slot plus trading off the soul steal. This would scale massively for obvious reasons, but imagine the combo possibilities! This is easily my most wanted move for new gen Shang! I literally wouldn't leave the lab.įinally, a move like Shinnok's mimicry could work for him. Speaking of combo potential, a gear move could be the possibility to amplify his soul steal, stunning for a combo. And don't get me started on the combo potential! This would allow Shang to pressure his opponent with his own strings, morph back, and continue his pressure himself. A move I would LOVE to have as gear though is a quick shape back, possibly with an AMP version that speeds it up. I definately would welcome a MK9 style soul steal, and that could be a base move. Now to the shapeshifting stuff: I would like to have a couple of string packs where Shang shapeshifts into various characters to do new strings as gear, although I don't want this to be his only shapeshifting move. ![]() This could have many uses in a game like MK11, but it should probably cost defensive bar, otherwise it might be too strong. Up skulls I can see come back also, we need a character with a move that functions like Sektor's up rockets after all.Īnother gear move I'd welcome dearly is his fire port also from the 3D era. ![]() I would like not to lose the straight skulls in the process though, but it depends on good it turns out to be I guess. It could function as a slower mid projectile (kind of like Reptile's force ball) and would compliment his ground skulls very nicely. Straight skulls are simple projectiles and I see no reason not to have them base roster, however his Fire Ring from the 3D era could come back as gear. This would mean that he always has zoning, but he needs to commit slots to get good damage off of it. Ground skulls are iconic and need to come back, but maybe the skull roller coaster could be gear. Click to expand.I would love for him to get mostly skulls in his base moveset, and Shapeshifting as his gear moves. |